Anticancer screening of several novel thienopyrimidines has been performed. The thienopyrimidine\nderivatives were synthesized from available starting materials according to the convenient\nsynthetic procedures using a one-pot solvent-free reaction which gave a wide access to\nthienopyrimidine-derivative production. The synthesized compounds were preselected via molecular\ndocking to be tested for their anticancer activity in NCI 60 cell lines. It was observed that some\ncompounds showed remarkable anticancer activity. It was found that the most active compound\namongthieno[2,3-d]pyrimidine-4(3H)- ones is 2-(benzylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-\n4(3H)-one, which possesses cytotoxic activity on almost all cancer cell lines with mean growth\n51.01%, where the most sensitive was the melanoma cell line MDA-MB-435 with GP (Growth Percent) ......... The patterns of structureâ??activity that are important for further optimization of the\nstructure and the creation of more selective and active anticancer agents were proposed.
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